This is a tough challenge, given that Windows 8 is only a few months away from release. There's not a lot that Microsoft can do in this time. However, given that the Redmond giant has already gone on the record to say that the UI that we see in the Windows 8 Release Preview is not what will be in the final release, it's safe to say that things are in a certain state of flux.
As I've said on numerous occasions, the biggest problem with Windows 8 is the way that the dumbed-down Metro UI has been unceremoniously bolted onto the mature and well-refined "Classic" user interface. While there's no doubt that the existing UI is flawed, bolting on a UI designed for touch devices is not the answer.
OK, you asked me to keep this concise, so here it is. Here's how I think Microsoft should tweak Windows 8 before it's released:
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How Microsoft can salvage Windows 8 before it's too late | ZDNet