When should you run a registry cleaner?

CCleaner's reg cleaner is pretty weak, therefore safe, I would not even classify it as reg cleaner.
But indeed, using good uninstallers is a great way to keep OS clean without using reg cleaners.
 

My Computer

System One

  • OS
    Win 8.1.1 Pro x64
    Computer type
    Laptop
    System Manufacturer/Model
    Lenovo E525
    CPU
    AMD A4-3300M @ 2,0GHz
    Memory
    6GB DDR3 1333MHz
    Graphics Card(s)
    AMD Radeon HD 6480G 512MB shared
    Sound Card
    Creative Sound Blaster X-Fi Surround 5.1
    Screen Resolution
    1366x768
    Hard Drives
    WD 465GB
    Cooling
    Fusion Tweaker
    Keyboard
    Logitech K360
    Mouse
    Logitech M705
    Internet Speed
    50/50 MBps
    Browser
    Yandex
    Antivirus
    No AV & No Firewall
    Other Info
    Headphones: Sennheiser RS170
CCleaner's reg cleaner is pretty weak, therefore safe, I would not even classify it as reg cleaner. :)
But seems to be most popular (undeservedly, looks like ). Other functions seem to be somewhat useful if used carefully and not going strictly by it's defaults. Of course, all of that could be accomplished other ways, mostly by using windows built in stuff. MS is missing a lot by not making such an centralized cleaning utility built into OS.
 

My Computer

System One

  • OS
    Windows 8.1 Pro
    Computer type
    PC/Desktop
    System Manufacturer/Model
    Home made
    CPU
    AMD Ryzen7 2700x
    Motherboard
    Asus Prime x470 Pro
    Memory
    16GB Kingston 3600
    Graphics Card(s)
    Asus strix 570 OC 4gb
    Hard Drives
    Samsung 960 evo 250GB
    Silicon Power V70 240GB SSD
    WD 1 TB Blue
    WD 2 TB Blue
    Bunch of backup HDDs.
    PSU
    Sharkoon, Silent Storm 660W
    Case
    Raidmax
    Cooling
    CCM Nepton 140xl
    Internet Speed
    40/2 Mbps
    Browser
    Firefox
    Antivirus
    WD
When I uninstalled windows office(cost to much and I use LibreOffice) after I bought my desktop, under Cleaner, Office kept showing up I used the reg cleaner and it didn't find anything. I had to use regedit and the find tool and manually delete it any how. When I update LibreOffice and run the reg cleaner it finds tons of stuff(mostly INI pointers and old settings).
 

My Computer

System One

  • OS
    Windows 8.1 Update Pro in Hyper-V/Windows 10 Pro 64 bit
    Computer type
    PC/Desktop
    System Manufacturer/Model
    Cliff's Black & Blue Wonder
    CPU
    Intel Core i9-9900K
    Motherboard
    ASUS ROG Maximus X Hero
    Memory
    32 GB Quad Kit, G.Skill Trident Z RGB Series schwarz, DDR4-3866, 18-19-19-39-2T
    Graphics Card(s)
    ASUS GeForce RTX 3090 ROG Strix O24G, 24576 MB GDDR6X
    Sound Card
    (1) HD Webcam C270 (2) NVIDIA High Definition Audio (3) Realtek High Definition Audio
    Monitor(s) Displays
    BenQ BL2711U(4K) and a hp 27vx(1080p)
    Screen Resolution
    1920 x 1080 x 32 bits (4294967296 colors) @ 60 Hz
    Hard Drives
    C: Samsung 960 EVO NVMe M.2 SSD
    E: & O: Libraries & OneDrive-> Samsung 850 EVO 1TB
    D: Hyper-V VM's -> Samsung PM951 Client M.2 512Gb SSD
    G: System Images -> HDD Seagate Barracuda 2TB
    PSU
    Corsair HX1000i High Performance ATX Power Supply 80+ Platinum
    Case
    hanteks Enthoo Pro TG
    Cooling
    Thermaltake Floe Riing RGB TT Premium-Edition 360mm and 3 Corsair blue LED fans
    Keyboard
    Trust GTX THURA
    Mouse
    Trust GTX 148
    Internet Speed
    25+/5+ (+usually faster)
    Browser
    Edge; Chrome; IE11
    Antivirus
    Windows Defender of course & Malwarebytes Anti-Exploit as a
    Other Info
    Router: FRITZ!Box 7590 AX V2
    Sound system: SHARP HT-SBW460 Dolby Atmos Soundbar
    Webcam: Logitech BRIO ULTRA HD PRO WEBCAM 4K webcam with HDR
ok so after reading 3 pages of registry cleaners are ok/not ok.. the question still remains... :

- how do you reset/rebuild - if possible, the registry without reinstalling windows..

I constantly uninstall and reinstall.. things like an old version of a program and then i reinstall a new version on top of it.. I think i would definitely like to "clean" out my registry because i always try out many many programs..

resetregistry.JPG
 

My Computer

System One

  • OS
    Windows 8.1 (HOME not Pro) 64bit
    Computer type
    Laptop
    System Manufacturer/Model
    (So not very nice) Lenovo Y410P
    CPU
    i7 quad 2.4Gig
    Memory
    16G ram
    Graphics Card(s)
    nvidia 2gig 755m
    Hard Drives
    Samsung 840 Evo

    supercache2 m2. mini card.
    Antivirus
    Win Defender
Prevention is the buzzword, use Revo Uninstaller to uninstall programs. Even bett, you ca install thru it (handy right click menu) and all the changes made by that program will be reverted once you uninstall it thru Revo.
 

My Computer

System One

  • OS
    Windows 8.1 Pro
    Computer type
    PC/Desktop
    System Manufacturer/Model
    Home made
    CPU
    AMD Ryzen7 2700x
    Motherboard
    Asus Prime x470 Pro
    Memory
    16GB Kingston 3600
    Graphics Card(s)
    Asus strix 570 OC 4gb
    Hard Drives
    Samsung 960 evo 250GB
    Silicon Power V70 240GB SSD
    WD 1 TB Blue
    WD 2 TB Blue
    Bunch of backup HDDs.
    PSU
    Sharkoon, Silent Storm 660W
    Case
    Raidmax
    Cooling
    CCM Nepton 140xl
    Internet Speed
    40/2 Mbps
    Browser
    Firefox
    Antivirus
    WD
The only way you "reset/rebuild" the registry is if you export a copy before installing a program(s) then import it after uninstalling that program(s)

Other than that there is Repair install.
 

My Computer

System One

  • OS
    Windows 8.1 Pro 64-bit
    Computer type
    Laptop
    System Manufacturer/Model
    Acer V3 771G-6443
    CPU
    i5-3230m
    Motherboard
    Acer VA70_HC (U3E1)
    Memory
    8GB DDR3 PC3-12800 (800 MHz)
    Graphics Card(s)
    HD4000 + GeForce GT 730M
    Sound Card
    Realtek High Definition Audio
    Monitor(s) Displays
    17" Generic PnP Display on Intel HD Graphics 4000
    Screen Resolution
    1600x900 pixels
    Hard Drives
    Samsung SSD 850 EVO 250 GB
    ADATA SSD SP900 128GB
    PSU
    90 watt brick
    Mouse
    Bluetooth
    Antivirus
    Comodo
    Other Info
    Asus RT-AC56R dual-band WRT router (Merlin firmware). Intel 7260.HMWWB.R dual-band ac wireless adapter.
I agree with Popeye there is really no way other than the way he said it without a reset or reinstall of windows. :D
 

My Computer

System One

  • OS
    Microsoft Windows 10 Pro 64-bit
    Computer type
    Laptop
    System Manufacturer/Model
    HP Pavilion DV6
    CPU
    Intel(R) Core(TM) i5 CPU M 460 @ 2.53GHz
    Motherboard
    Hewlett-Packard 144C
    Memory
    6 GB soon to be 8 GB
    Graphics Card(s)
    Intel(R) HD Graphics (Core i5)
    Sound Card
    IDT High Definition Audio CODEC
    Screen Resolution
    1366 x 768 x 32 bits (4294967296 colors) @ 60 Hz
    Hard Drives
    1 TB Samsung HDD and Samsung 600 GB SSD
    Case
    HP metal case.
    Cooling
    Standard fan ( Does a good enough job)
    Keyboard
    HP backlit keyboard.
    Mouse
    Standard USB Mouse
    Internet Speed
    60 Mbps Download and 10 Mbps Upload thru Charter High Speed Internet
    Browser
    Firefox and Internet Explorer
    Antivirus
    Norton Internet Security
    Other Info
    Custom Built Windows Server 2008 R2 used for storage server, DHCP server, Primary DNS server. Novell Suse Server running 2 custom built desktop that have Novell Netware installed. Samsung Note 3 (Primary Phone) and Samsung S4 (Back up phone).
:ditto:
 

My Computer

System One

  • OS
    Windows 8.1.1 Pro with Media Center
    Computer type
    PC/Desktop
    System Manufacturer/Model
    Gateway
    CPU
    AMD K140 Cores 2 Threads 2 Name AMD K140 Package Socket FT1 BGA Technology 40nm
    Motherboard
    Manufacturer Gateway Model SX2110G (P0)
    Memory
    Type DDR3 Size 8192 MBytes DRAM Frequency 532.3 MHz
    Graphics Card(s)
    ATI AMD Radeon HD 7310 Graphics
    Sound Card
    AMD High Definition Audio Device Realtek High Definition Audio USB Audio Device
    Monitor(s) Displays
    Name 1950W on AMD Radeon HD 7310 Graphics Current Resolution 1366x768 pixels Work Resolution 1366x76
    Screen Resolution
    Current Resolution 1366x768 pixels Work Resolution 1366x768 pixels
    Hard Drives
    AMD K140
    Cores 2
    Threads 2
    Name AMD K140
    Package Socket FT1 BGA
    Technology 40nm
    Specification AMD E1-1200 APU with Radeon HD Graphics
    Family F
    Extended Family 14
    Model 2
    Extended Model 2
    Stepping 0
    Revision ON-C0
    Instruction
    Browser
    Opera 24.0
    Antivirus
    Avast Internet Security
I love Revo Uninstaller one of the best, but using it many times it still leaves leftovers, so i can imagine what's in registry still, not to say i am going to go look for it. I do find folders and files in ProgramFiles(x86), Users, etc... from uninstalled programs using Revo.

Truthfully what i am saying is there is no uninstaller that gets it all, no matter how good they say it is. One option in Revo is to install it with Revo, find that in the context menu, that way may be more possible it will be able to find everything when uninstalled, as i believe it monitors it better.

But will removing majority or some of those registry entries really matter, probably not, some maybe. Unless like some were saying causing an error and you know what you are doing when removing one or two. I try to also rely on a system restore point, also as said, can export a registry backup first before doing anything. True CCleaner is pretty safe and even find some of those leftovers registry entries from uninstalled programs and has a export feature.

As for Registry cleaners as most of you said, if not familiar with working with the registry, do not fool with it then, if it ain't broken don't try to fix it.
 

My Computer

System One

  • OS
    Windows 10 Pro 64bit
    Computer type
    PC/Desktop
    System Manufacturer/Model
    CyberPowerPC Gamer Xtreme 1502 (GX1502)
    CPU
    Intel Core i7 5820K 3.30 GHZ 64 bit 6-Core Processor
    Motherboard
    Gigabyte GA-X99-UD3
    Memory
    G.Skill 16GB Quad Channel DDR4-2400MHZ
    Graphics Card(s)
    EVGA GeForce GTX 970 SSC ACX 2.0+ DDR5 4GB
    Sound Card
    Creative Sound Blaster ZxR 5.1
    Monitor(s) Displays
    ASUS PA24Q 24" Pro Art IPS LCD/LED Backlit 1920x1200
    Screen Resolution
    1920x1200 16:10
    Hard Drives
    SAMSUNG 850 EVO 250GB SATA 6Gb/s 2.5" Internal SSD,
    Crucial MX100 512GB SATA 6Gb/s 2.5" Internal SSD,
    WD WD10EZEX-00RKKA0 1TB SATA 6Gb/s 3.5 Internal HDD
    PSU
    EVGA SuperNOVA 750 G2 750W 80 Plus Gold Full Modular
    Case
    AZZA Cosmas Black Gaming Case
    Cooling
    Cool Master Hyper 212 Evo Dual 120mm, ( 2) Noctua PWM 120mm Case Fans (1) Gelid PWM 120mm Blue LED
    Keyboard
    Logitech K800 Illumiated Wireless Keyboard
    Mouse
    Logitech M570 Wireless Trackball
    Internet Speed
    84mbps /94mbps
    Browser
    Mozilla Firefox 41.0.1 / Microsoft Edge/ IE 11
    Antivirus
    Norton Security 2015
    Other Info
    Pioneer BDR-209DBK 16x Blu-Ray Burner, LG 24x Dual Layer DVD Burner,
    StarTech Front Bay 22-in-1 USB 2.0 Internal Multi Media Memory Card Reader,Logitech Z906 5.1 Speaker system
ok so after reading 3 pages of registry cleaners are ok/not ok.. the question still remains... :

- how do you reset/rebuild - if possible, the registry without reinstalling windows..

I constantly uninstall and reinstall.. things like an old version of a program and then i reinstall a new version on top of it.. I think i would definitely like to "clean" out my registry because i always try out many many programs..

View attachment 55815

See post #13 this tool will back up and restore a registry, then you can use the Windows Repair (all in one) to reset all registry permissions. I've been using this for years and has saved me from having to do a system reimage(I always keep a virgin one from a fresh install w/updates on an external HDD in the closet).
 

My Computer

System One

  • OS
    Windows 8.1 Update Pro in Hyper-V/Windows 10 Pro 64 bit
    Computer type
    PC/Desktop
    System Manufacturer/Model
    Cliff's Black & Blue Wonder
    CPU
    Intel Core i9-9900K
    Motherboard
    ASUS ROG Maximus X Hero
    Memory
    32 GB Quad Kit, G.Skill Trident Z RGB Series schwarz, DDR4-3866, 18-19-19-39-2T
    Graphics Card(s)
    ASUS GeForce RTX 3090 ROG Strix O24G, 24576 MB GDDR6X
    Sound Card
    (1) HD Webcam C270 (2) NVIDIA High Definition Audio (3) Realtek High Definition Audio
    Monitor(s) Displays
    BenQ BL2711U(4K) and a hp 27vx(1080p)
    Screen Resolution
    1920 x 1080 x 32 bits (4294967296 colors) @ 60 Hz
    Hard Drives
    C: Samsung 960 EVO NVMe M.2 SSD
    E: & O: Libraries & OneDrive-> Samsung 850 EVO 1TB
    D: Hyper-V VM's -> Samsung PM951 Client M.2 512Gb SSD
    G: System Images -> HDD Seagate Barracuda 2TB
    PSU
    Corsair HX1000i High Performance ATX Power Supply 80+ Platinum
    Case
    hanteks Enthoo Pro TG
    Cooling
    Thermaltake Floe Riing RGB TT Premium-Edition 360mm and 3 Corsair blue LED fans
    Keyboard
    Trust GTX THURA
    Mouse
    Trust GTX 148
    Internet Speed
    25+/5+ (+usually faster)
    Browser
    Edge; Chrome; IE11
    Antivirus
    Windows Defender of course & Malwarebytes Anti-Exploit as a
    Other Info
    Router: FRITZ!Box 7590 AX V2
    Sound system: SHARP HT-SBW460 Dolby Atmos Soundbar
    Webcam: Logitech BRIO ULTRA HD PRO WEBCAM 4K webcam with HDR

My Computer

System One

  • OS
    Windows 8.1 Pro
    Computer type
    PC/Desktop
    System Manufacturer/Model
    Home made
    CPU
    AMD Ryzen7 2700x
    Motherboard
    Asus Prime x470 Pro
    Memory
    16GB Kingston 3600
    Graphics Card(s)
    Asus strix 570 OC 4gb
    Hard Drives
    Samsung 960 evo 250GB
    Silicon Power V70 240GB SSD
    WD 1 TB Blue
    WD 2 TB Blue
    Bunch of backup HDDs.
    PSU
    Sharkoon, Silent Storm 660W
    Case
    Raidmax
    Cooling
    CCM Nepton 140xl
    Internet Speed
    40/2 Mbps
    Browser
    Firefox
    Antivirus
    WD

My Computer

System One

  • OS
    Windows 10 Pro 64bit
    Computer type
    PC/Desktop
    System Manufacturer/Model
    CyberPowerPC Gamer Xtreme 1502 (GX1502)
    CPU
    Intel Core i7 5820K 3.30 GHZ 64 bit 6-Core Processor
    Motherboard
    Gigabyte GA-X99-UD3
    Memory
    G.Skill 16GB Quad Channel DDR4-2400MHZ
    Graphics Card(s)
    EVGA GeForce GTX 970 SSC ACX 2.0+ DDR5 4GB
    Sound Card
    Creative Sound Blaster ZxR 5.1
    Monitor(s) Displays
    ASUS PA24Q 24" Pro Art IPS LCD/LED Backlit 1920x1200
    Screen Resolution
    1920x1200 16:10
    Hard Drives
    SAMSUNG 850 EVO 250GB SATA 6Gb/s 2.5" Internal SSD,
    Crucial MX100 512GB SATA 6Gb/s 2.5" Internal SSD,
    WD WD10EZEX-00RKKA0 1TB SATA 6Gb/s 3.5 Internal HDD
    PSU
    EVGA SuperNOVA 750 G2 750W 80 Plus Gold Full Modular
    Case
    AZZA Cosmas Black Gaming Case
    Cooling
    Cool Master Hyper 212 Evo Dual 120mm, ( 2) Noctua PWM 120mm Case Fans (1) Gelid PWM 120mm Blue LED
    Keyboard
    Logitech K800 Illumiated Wireless Keyboard
    Mouse
    Logitech M570 Wireless Trackball
    Internet Speed
    84mbps /94mbps
    Browser
    Mozilla Firefox 41.0.1 / Microsoft Edge/ IE 11
    Antivirus
    Norton Security 2015
    Other Info
    Pioneer BDR-209DBK 16x Blu-Ray Burner, LG 24x Dual Layer DVD Burner,
    StarTech Front Bay 22-in-1 USB 2.0 Internal Multi Media Memory Card Reader,Logitech Z906 5.1 Speaker system

My Computer

System One

  • OS
    Windows 8.1 Pro 64-bit
    Computer type
    Laptop
    System Manufacturer/Model
    Acer V3 771G-6443
    CPU
    i5-3230m
    Motherboard
    Acer VA70_HC (U3E1)
    Memory
    8GB DDR3 PC3-12800 (800 MHz)
    Graphics Card(s)
    HD4000 + GeForce GT 730M
    Sound Card
    Realtek High Definition Audio
    Monitor(s) Displays
    17" Generic PnP Display on Intel HD Graphics 4000
    Screen Resolution
    1600x900 pixels
    Hard Drives
    Samsung SSD 850 EVO 250 GB
    ADATA SSD SP900 128GB
    PSU
    90 watt brick
    Mouse
    Bluetooth
    Antivirus
    Comodo
    Other Info
    Asus RT-AC56R dual-band WRT router (Merlin firmware). Intel 7260.HMWWB.R dual-band ac wireless adapter.
I only recommend CCleaner and I use it about once a month.
 

My Computer

System One

  • OS
    Win 10 Pro 64bit
    Computer type
    PC/Desktop
    System Manufacturer/Model
    Home built Intel i7-3770k-based system
    CPU
    Intel i7-3770k, Overclocked to 4.6GHz (46x100) with Corsair H110i GT cooler
    Motherboard
    ASRock Z77 OC Formula 2.30 BIOS
    Memory
    32GB DDR3 2133 Corsair Vengeance Pro
    Graphics Card(s)
    GeForce GTX 980ti SC ACS 6GB DDR5 by EVGA
    Sound Card
    Creative Sound Blaster X-Fi Titanium HD, Corsair SP2500 speakers and subwoofer
    Monitor(s) Displays
    LG 27EA33 [Monitor] (27.2"vis) HDMI
    Screen Resolution
    1920x1080
    Hard Drives
    Samsung SSD 850 EVO 250GB (system drive)
    WD 6TB Red NAS hard drives x 2 in Storage Spaces (redundancy)
    PSU
    Corsair 750ax fully modular power supply with sleeved cables
    Case
    Corsair Air 540 with 7 x 140mm fans on front, rear and top panels
    Cooling
    Corsair H110i GT liquid cooled CPU with 4 x 140" Corsair SP "push-pull" and 3 x 140mm fans
    Keyboard
    Thermaltake Poseidon Z illuminated keyboard
    Mouse
    Corsair M65 wired
    Internet Speed
    85MBps DSL
    Browser
    Chrome and Edge
    Antivirus
    Windows Defender, MalwareBytes Pro and CCleaner Pro
    Other Info
    Client of Windows Server 2012 R2 10 PC's, laptops and smartphones on the WLAN.

    1GBps Ethernet ports
I use it after uninstalling something.
 

My Computer

System One

  • OS
    Windows 8.1.1 Pro with Media Center
    Computer type
    PC/Desktop
    System Manufacturer/Model
    Gateway
    CPU
    AMD K140 Cores 2 Threads 2 Name AMD K140 Package Socket FT1 BGA Technology 40nm
    Motherboard
    Manufacturer Gateway Model SX2110G (P0)
    Memory
    Type DDR3 Size 8192 MBytes DRAM Frequency 532.3 MHz
    Graphics Card(s)
    ATI AMD Radeon HD 7310 Graphics
    Sound Card
    AMD High Definition Audio Device Realtek High Definition Audio USB Audio Device
    Monitor(s) Displays
    Name 1950W on AMD Radeon HD 7310 Graphics Current Resolution 1366x768 pixels Work Resolution 1366x76
    Screen Resolution
    Current Resolution 1366x768 pixels Work Resolution 1366x768 pixels
    Hard Drives
    AMD K140
    Cores 2
    Threads 2
    Name AMD K140
    Package Socket FT1 BGA
    Technology 40nm
    Specification AMD E1-1200 APU with Radeon HD Graphics
    Family F
    Extended Family 14
    Model 2
    Extended Model 2
    Stepping 0
    Revision ON-C0
    Instruction
    Browser
    Opera 24.0
    Antivirus
    Avast Internet Security
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