I run a bunch of Logitech cordless devices, trackballs, keyboards, and a track pad. They are all Unifying. They all work without having to install Setpoint. All the basic stuff works anyway. There are some custom keys on my keyboard that don't work but its nothing really needed for general use. Just a bunch of shortcut keys for office etc. If you hunt around on the Logitech site you can find the stand alone Unifying installer. I've installed it so I can link and unlink devices from the unifying receiver. My keyboard came with a mouse that I don't use. I just linked the keyboard to the receiver that came with my Trackball. Then I unlinked the keyboard from its original receiver and gave the mouse and receiver to my Dad. I did have to install Setpoint on the PC my track pad is used on, otherwise I don't get any 2 finger scroll and other gestures. Point and click still works, I just don't get the support for gestures. I like being able to mix and match devices with the unifying receivers.