Ok, so lid closed and plugged into the hub, I had a crash after about 4 hours of straight work.
Conditions:
1) woke the computer from sleep using the mouse prior to starting work using the machine
2) 4 hours later, computer crashed when using mouse to highlight text on a webpage for copying. Crashes have happened in the past during this same action, or on attempting to paste, etc. But not exclusively.
So, it has to be related to one or a combo of the following:
1) Having the lid closed and plugged into hub.
2) Waking computer from sleep using the mouse or keyboard though crash happens some time later.
3) Some weird issue related to the mouse itself in combination with having the lid closed.
I had some troubles with the touchscreen becoming disabled after disconnecting from the hub early on. But think I solved that problem by shutting the machine down before disconnecting, which is inconvenient but I can deal with it.
Thoughts on how to further troubleshoot?