Unless you hace altered any of the defaults, it should be on already. But if you have installed any third party anti Virus programs, many automatically turn it off.
Open Defender. You can do this from the Control Panel. Click Settings and it should show you that Defender is running in "Real" mode.
If not, my first remark applies, and you may have to consider if you wish to keep the third party program, or use Defender instaed.