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Windows 10 fixes the problem.

Ok. Although I've only installed windows a month or two ago.

Thanks, I'll try these next time.

Scan complete: "Windows Resource Protection did not find any integrity violations."

Didn't think of ALT-F4, does that still work in Windows 8?

Ah thanks, I'll try WIN-C next time, I forgot what the bar was called - "charms" is not very intuitive. Running sfc /scannow......

It just did it again, and it's not restricted to the mouse. I cannot use the windows key on the keyboard (I can if I kill explorer.exe and start explorer.exe again in the task manager), or get to the active corners, making it impossible to shut down the machine properly. Does anybody know a...

Could be a bit messy. It's a Dell standard optical mouse, which is manufactured by Logitech. So I installed Logitech drivers so I could reprogram the middle button. I've also got a utility installed so using the wheel correctly scrolls what's under the cursor, instead of the application in...

Not sure how the mouse driver could help as I could click the desktop just fine, but I'll try if it happens again. It seems to have fixed itself.

This happens about once every 2 or 3 weeks. Suddenly (in this case I alt-tabbed from a game (Civ 5) to a web browser (Opera)), and found nothing I clicked would do anything. Except the desktop, that worked. It was as though there was a pane of glass between the cursor and all the programs. I...