Solved Screen flashes then mouse becomes unresponsive.

Okay. Hello everyone, since this is my first post. I shall introduce myself. I am Thomas, and I have many years of computer experience. I can usually solve my PC related issues by either experience or googling to find a solution. However, to this point I have yet to find a satisfactory solution to this problem. I shall start by giving as much background information as possible.

SYSTEM (Custom build in January 2015)
Motherboard: ASUS Sabertooth X99
CPU: Intel Core i7 5820K
GPU: Sapphire Radeon VAPOR-X R9 290X 8GB GDDR5
Memory: 32 GB DDR4 memory
OS Drive: SAMSUNG XP941 M.2 512GB PCI-Express 2.0 x4 MLC SSD
Data drives: 2x Western Digital Red 3 TB drives in RAID 1 on INTEL hardware raid controller
ODD: LG 16 x Blu-ray burner.
PSU: Corsair AX1200i
Case: Corsair Carbide 540 series
CPU Cooler: Corsair H110
OS: Windows 8.1 Professional (Clean Install 2015-08-02) All applicable updates installed. all drivers up-to-date.
Keyboard: Microsoft Sculpt Ergonomic Desktop Keyboard
Mouse: Logitech MX Master (same issue with other mice as well)
Monitors: Dell U3415W connected via Displayport to HDMI adapter and HDMI cable.
Vizio M65-C1 4K smart LED HDTV connected through Sony STR-DN1050 AVR via HDMI
AV Software: Malware-bytes Anti-malware Pro.
Symantec Endpoint Protection
Browser: Google Chrome

ISSUE
The issue, which I am experiencing is both monitors will flash to a black screen and come back on like normal after 1-2 seconds. When the screen comes back on, the mouse no longer functions normally. I can still move the mouse around the screen. However, I am no longer able to click on anything. When I attempt to click on something the Computer emits two beeps from the speakers (Not the on-board speaker), one when I depress the mouse button and one when I release the mouse button. Sometimes when I move the mouse I see the pointer moving but I also see another pointer at the same time frozen on the screen. Sometimes the beeping noise occurs when I move the mouse other times it doesn't The keyboard and all other functions continue to operate normally. The only remedy is to restart the computer. Upon restart the system operates normally.

The issue occurs infrequently. Sometimes I can go a week between restarts, other times I can only go 24 hours between restarts. Also, I do not game using this computer whatsoever.

TROUBLESHOOTING COMPLETED
This issue has persisted over multiple fresh installs. No pirated software is installed. Antivirus and Anti-malware scans detect no malicious or other harmful software. I have tested different and known good cables. I have tested other mice. All wireless (I unfortunately don't have any wired mice available.) Other articles or forum post, which I have found with the same or similar problem but with no solution. include:

http://www.eightforums.com/general-support/57340-continuous-beeping-laggy-mouse.html
https://superuser.com/questions/569...-beeps-laggy-keyboard-key-presses-on-pc-start
https://superuser.com/questions/849517/mouse-malfunction-with-beeping-noise

Here is a link to a video of the issue as reported by someone else.
https://www.youtube.com/watch?v=DaWUfftBQVU

My apologies in advance if I have forgotten to mention anything, or left out some information. If you have any specific questions feel free to ask and I will answer them to the best of my ability. Thanks in advance for your assistance.

That is one heck of a machine not to be used for gaming, unless your using it for stuff like Photoshop, Illustrator, CAD, etc.

There have been many other users that have reported this issue. Some claim to have fixed it by uninstalling Logitech Setpoint if you have it installed. Others have claimed to fix it by unplugging other USB devices that were connected. It seems though that there has yet to be one unified solution to this issue. I would suggest starting by looking for any conflicting software (like the Setpoint that I mentioned) and then trying unplugging and replugging any USB hardware to see if it cures the issue.

As it stands, It really seems to be a USB issue of some sort, but all the further that it has gotten (to my knowledge.) The only thing I can figure is it might be in the way that Windows 8 handles USB connections, but I think I have also heard of the issue showing up in Windows 7 and 10 as well. Its hard to say. Im really wondering if it isnt a certain USB chipset that is causing the issue, or certain ones that are all in the same family.