Cannot open anything with setup.exe ,help pls

Hi I am running windows 8.1 and today had a small program(EMDB) I had to install with the name setup.exe when i click on it to open it even in admin mode it gives me this error "windows cannot find setup.exe make sure you typed named correctly and try again."
No matter what it is , as long as it has those words setup.exe. I even changed a different title from its original name to setup.exe and same error. I did a sfc with no erros. I am figuring a registry error, anyone with ideas?

Thks

wrong answer, sorry

pls close i ran a reg cleaner wisecare problem is fixed for some reason. Thks