You will have to fully disable UAC by setting the EnableLUA key.
Instead of disabling the UAC system, I would suggest putting your keepass database into a folder within My Documents or elsewhere where you can save.
It's a bad idea to save data that is updated, such as a database, in Program Files. This folder is intended for read-only data, other than when installing new apps. This prevents malware from easily accessing program files and modifying applications.
Any data you have should be saved either in your user profile (such as Documents), or on an external device.
If you do that and set it to 0 instead of 1, then you will not be able to run Metro apps afterwards. This is no longer the same in Windows 8. It must be left set to 1.
User Account Control (UAC) - Change Settings in Windows 8
If one wants full control, then they could enable the built-in Administrator account, and sign in to it instead. Be sure to read the warning in the tutorial below first.
Built-in Administrator Account - Enable or Disable - Windows 7 Forums