Microsoft does not recommend relocating, moving Program Files, Program Files (x86) and Windows folders. Too much is depending on information and data stored on these three folders. However, there's simply nothing preventing us to move the other three. In this tutorial we move, relocate, the Programdata and Users folders.
Moving both Users and ProgramData folders can save a lot of space on system disk. Pictures, mp3ís videos, documents and so on, a user folder with its subfolders can be tens, sometimes hundreds of gigabytes.
Personally, when installing Windows 8 I always use Audit Mode to relocate Users and ProgramData, leaving system drive only for Windows and applications.