Mouse not working after installing 8.1, again after update

I did a clean re-install of Windows 8.1 as I had numerous problems due to malware, etc with 8.1.
After installing Windows (no problem during installation), I started to install my software, and often had to restart my PC as required by some programs.
After one of these restarts, the mouse and keyboard did not work. I replaced the batteries (it is a wireless Microsoft mouse (MS Wireless Mouse 1000; Model 1454) and keyboard (MS Wireless Keyboard 800;Model 1455))-this (batteries) in the past have often been the problem. No luck.
I then tried another wired mouse and keyboard, which also did not work. I took it to my technician. He used his own mouse and keyboard, which worked, but at home the same sage with both sets, continued.
I searched the internet, but mostly the answers were aimed as if you have a working mouse and keyboard-click on this; open command prompt; etc.
I made no progress. I suspected that the drivers needed to be updated. I spent hours researching the subject and tried various options.
I then decided to re-install Windows 8.1. The Microsoft keyboard and mouse still did not work after this installation. I took it to the technician again, his mouse and keyboard again worked on my PC. I bought a wired mouse and keyboard. After that the system was working very well. I installed all my programs, editing videos, etc.
Two nights ago there was a Windows Update-must have been a big update as it took quite a while to install.
When I next tried to work on the PC, the mouse did (still does) not work. I tried 2 other pairs of keyboards and mice - keyboards working; mice not. (I cannot see the mouse pointer and nothing happens when I click the mouse)
I then downloaded all updates for the MSI drivers with another PC, put it on a memory stick. Now I am clueless how to install them without a mouse. I looked up all possible keyboard shortcuts, but for me this is a big job to even get to a folder, let alone opening and installing them.
So, my queries:

1. The drivers need to be updated, I know. If it will solve the issue, I do not know.
2. Any other possibilities?

But first if someone can guide me how to install the drivers without a mouse (currently on a USB stick as I said) would be a big help.

Any HID compatible device should work without any special drivers. Have you tried Safe Mode to see if it works?

I had similar problem with acer laptop, what ever driver I installed none worked... etc...
Solved the problem by updating BIOS from acer website.

So you might look at:
ECS > G41T-M (V2.0)

and install their stuff, however I can't see any updates for Windows 8.1 there

I think that ECS is wrong. Apologies. I copied the info from the Windows 7 forum, but if the ECS refers to the motherboard, I have now a MSI motherboard: H61M-P21(B3). (I have very much a hybrid system!)
I have downloaded all the updates from the MSI website and it is on a memory stick, but I do not know how to install it. I tried the MouseKeys, but I do not see a mouse pointer on the screen.
If I make the memory stick bootable, will it then install it?

avz10 said:

If I make the memory stick bootable, will it then install it?

Click to expand...

Dude, just a side note, updating BIOS should be taken with care, if something goes wrong you'll have to take your PC to technician.

There is a manual on their site, you should read it carefully if you wanna take the risk.

In your opinion, what are the options? If I could uninstall the update, I suppose that would fix it. But again how? Or other possibilities??