Even if you pay $10,000 for a system and its hardware is extreme to the max, still should always close all applications before gaming.
I would uninstall this software, just simply because it is an unnecessary driver to have:
The issue odds-wise, is likely from ASUS Xonar:
HWiNFO64A HWiNFO64A.SYS Fri Nov 22 10:45:10 2013 (528F7C06)
See if there is an update, but even still if so, I'd be tempted to run integrated audio with Xonar hardware physically removed, to test.
cmudaxp cmudaxp.sys Wed Sep 26 04:29:02 2012 (5062BCCE)
CMUSBDAC CMUSBDAC.sys Sat Sep 14 02:39:46 2013 (523404B2)
Update motherboard bios to newest and also check memory timings and frequency with CPU-Z to be correct for the modules you have.
Most important thing to say of it all:
bwcW8x64 bwcW8x64.sys Wed Feb 13 12:25:48 2013 (511BCC9C)